Fig. 1. Oxymatrine protected INS-1 cells from pyroptosis.
(A) The electron microscopic analysis of different cells. Scale bar: 2 μm; Oxymatrine: 10 μM. (B) Representative graphics from flow cytometry analysis were showed; Oxymatrine: 10 μM. (C) The caspase-1 activity analysis of different cells; Oxymatrine: 10 μM. (D) The LDH release analysis of different cells. control: no treatment; HG: high glucose (30 mM glucose); PA: palmitic acid sodium (400 μM). Arrows: the autophagosomal vesicles. Data are presented as mean ± SD and represent an average of three experiments. LDH, lactate dehydrogenase. **p < 0.01 vs. control, ##p < 0.01 vs. HG + PA; the experiments were repeated three times.
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