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Fig. 8. Effect of IMP combined with DOX on P-gp expression in K562/DOX xenograft tumors in NOD/SCID mice. (A) Representative Western blots of P-gp protein. Quantified data showing IMP at dosage of 10 mg/kg and 20 mg/kg combined with DOX (2.5 mg/kg) treatments inhibited P-gp protein expression (B) and mRNA level (C) in K562/DOX xenograft tumor tissues as compared with DOX (2.5 mg/kg) alone treatment. Data are presented as the means ± SD, n = 8. IMP, imperatorin; DOX, doxorubicin; P-gp, P-glycoprotein. **p < 0.01 vs. untreated model group. ##p < 0.01 vs. DOX (2.5 mg/kg) alone group.
Korean J Physiol Pharmacol 2022;26:145-155
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