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Fig. 7. Effect of IMP combined with DOX on pathological abnormalities of K562/DOX xenograft tumors in NOD/SCID mice. (A) Tumor tissues were fixed, sectioned, and stained with H&E (magnification, ×50). The blue arrows indicate that the cell structure was seriously damaged and the cell density was enhanced. (B) Electron microscope observation of tumor tissues subjected to different treatments with IMP (10 and 20 mg/kg) and DOX (2.5 mg/kg). The red arrows indicated mitochondria indicates that the cells have shrinkage, necrosis, cytoplasmic vacuoles. The orange arrows were more obvious mitochondrial structure. The green arrows pointed out the mitochondrial morphology of normal cells. IMP, imperatorin; DOX, doxorubicin.
Korean J Physiol Pharmacol 2022;26:145-155
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