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Fig. 6. Effect of IMP combined with DOX on tumor growth of K562/DOX xenograft tumors in NOD/SCID mice. (A) The tumor volumes were measured at 0, 7, and 14 days. (B) The tumor weights were analyzed after 14 days. (C) Representative images of tumor tissues subjected to different treatments of DOX and IMP (1, untreated model group; 2, DOX 2.5 mg/kg alone group; 3, IMP 10 mg/kg + DOX 2.5 mg/kg group; 4, IMP 20 mg/kg + DOX 2.5 mg/kg group). Data are shown as means ± SD, n = 8. IMP, imperatorin; DOX, doxorubicin. *p < 0.05; **p < 0.01 vs. untreated model group. ##p < 0.01 vs. DOX 2.5 mg/kg alone group.
Korean J Physiol Pharmacol 2022;26:145-155 https://doi.org/10.4196/kjpp.2022.26.3.145
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