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Fig. 5. IMP restrained the glycolysis and glutamine metabolism of K526/DOX cells in vitro. (A) DOX promoted the expression of P-gp. (B, C) The glucose consumption, lactate production and ECAR were measured to assess cell glycolysis. (D, E) Glutamine consumption, α-KG production and ATP production were determined using corresponding Assay Kits, respectively. K562/DOX cells treated with 0 and 2.8 µM IMP. IMP, imperatorin; DOX, doxorubicin; P-gp, P-glycoprotein; ECAR, extracellular acidification rate; α-KG, α-ketoglutaric acid; 2-DG, 2-deoxy-D-glucose. **p < 0.01.
Korean J Physiol Pharmacol 2022;26:145-155
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