Table. 2.

IC50 value in A2780 cells and A2780/Taxol cells

Group IC50 (µM) RI RF
A2780 A2780/Taxol
Taxol 51.33 ± 1.76 188.30 ± 4.63* 3.67 -
Taxol + IMP (7.40 µM) 52.84 ± 1.18 83.29 ± 2.21*,† 1.58 2.32
Taxol + IMP (18.50 µM) 56.89 ± 2.01 71.05 ± 2.13*,† 1.25 2.94
Taxol + IMP (37.00 µM) 51.57 ± 2.11 35.53 ± 1.17*,† 0.69 5.32

Data are shown as means ± SD, n = 3. A2780 and A2780/Taxol cells were incubated with various concentrations of Taxol (0.76–97.12 µM) in the presence or absence of IMP (7.40, 18.50, 37.00 µM) for 48 h, respectively. The cytotoxicity was evaluated by CCK-8 assay. IC50 (µM) values were calculated using the Bliss method. RI was calculated by dividing the IC50 for A2780/Taxol cells by that of A2780 cells. RF was calculated as the ratio between the IC50 value of Taxol alone to that of IMP combined with Taxol in A2780/Taxol cells. IC50, 50% inhibiting concentration; Taxol, Taxinol; RI, resistance index; RF, reversal fold; IMP, imperatorin; CCK-8, Cell Counting Kit-8. *p < 0.05 vs. respective A2780 cells; †p < 0.05 vs. respective Taxol alone group.

Korean J Physiol Pharmacol 2022;26:145-155 https://doi.org/10.4196/kjpp.2022.26.3.145
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