Fig. 1. Effects of CORM-2 on ANP secretion and atrial contractility.
(A) Effects of CORM-2 (10, 50, 100 µM) on ANP secretion (a), SAP (b), DAP (c) and APP (d) as a function of time in high-stretched atria. (B) Relative percent changes in atrial parameters by CORM-2. Values are expressed by the relative percent change from the mean of the first five control values (fraction no. 1–5) and the last five peak values (fraction no. 21–25). Values are expressed as the means ± SEM. Arrow indicates the time to start to perfuse CORM-2 with high atrial stretch. CORM, carbon monoxide releasing molecule; ANP, atrial natriuretic peptide; SAP, systolic atrial pressure; DAP, diastolic atrial pressure; APP, atrial pulse pressure. *** vs. vehicle group, p < 0.005; # vs. corresponding group, p < 0.05, ##p < 0.01.
© Korean J Physiol Pharmacol
