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Fig. 5. Lithium chloride recovers a reduction in GSK3β phosphorylation levels in the NAcc shell. Representative Western blots are shown. Values for the band intensities were first normalized to β-actin and then the average values for the ratio of phosphorylated to total proteins in each group were expressed as group mean + SEM relative to saline challenged Control group. Symbols indicate significant differences as revealed by post-hoc Bonferroni comparisons following two-way ANOVA. *p < 0.05, significantly different compared to Control group. ††p < 0.01, significantly different from no lithium chloride treated the Paired group. Lithium chloride treatment also recovered the lowered GSK3β phosphorylation levels in the Paired group, but it did not reach statistical significance, in the NAcc core. Numbers for each group are 8. GSK3β, glycogen synthase kinase 3β; NAcc, nucleus accumbens; CTL, control; LiCl, lithium chloride.
Korean J Physiol Pharmacol 2022;26:59-65
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