Fig. 5. Double immunohistofluorescence for GFAP (green) and GLUT-1 (red) in the CA1 region of the Sham-vehicle (A), TFI-vehicle (B–D), Sham-20 mg/kg STP (E) and TFI-20 mg/kg STP (F–H) groups six hours (B and F), two days (C and G) and five days (D and H) after TFI.
GFAP+ AEF (arrows in A) are contact with GLUT-1+ endothelial cells in the Sham-vehicle group; however, in the TFI-vehicle group, AEF disappear gradually (arrows in B–D). In contrast, GFAP+ AEF (arrows in F–H) are well co-localized with GLUT-1+ endothelial cells in the TFI-20 mg/kg STP group. Scale bars = 50 μm. GFAP, glial fibrillary acidic protein; GLUT-1, glucose transporter 1; CA1, cornu ammonis 1; TFI, transient forebrain ischemia; STP, stiripentol; AEF, astrocyte endfeet; SP, stratum pyramidale; SR, stratum radiatum.
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