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Fig. 4. (A) GFAP immunohistochemistry in the CA1 region of the Sham-vehicle (a), TFI-vehicle (b–d), Sham-20 mg/kg STP (e) and TFI-20 mg/kg STP (f–h) groups six hours (b and f), two days (c and g) and five days (d and h) after TFI. In the TFI-vehicle group, GFAP+ astrocytes become gradually hypertrophied after TFI, showing that the ends of the astrocytes are blunt (arrow) five days after TFI. In contrast, the hypertrophy of GFAP+ astrocytes is apparently attenuated in the TFI-20 mg/kg STP group. Scale bars = 100 μm. (B) ROD of GFAP immunoreactive structures. The bars indicate the means ± SEM (n = 5 or 7, respectively; *p < 0.05 vs. Sham-vehicle or Sham-STP group; #p < 0.05 vs. TFI-vehicle group). GFAP, glial fibrillary acidic protein; CA1, cornu ammonis 1; TFI, transient forebrain ischemia; STP, stiripentol; ROD, relative optical density; SO, stratum oriens; SP, stratum pyramidale; SR, stratum radiatum.
Korean J Physiol Pharmacol 2022;26:47-57 https://doi.org/10.4196/kjpp.2022.26.1.47
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