Fig. 3. (A–H and a–h) NeuN immunohistochemistry (A–H) and F-J B histofluorescence (a–h) in the CA1 region of the Sham-vehicle (A and a), TFI-vehicle (B and b), Sham-STP (10, 15, and 20 mg/kg) (C, c, E, e, G, and g) and TFI-STP (10, 15, and 20 mg/kg) (D, d, F, f, H, and h) groups five days after TFI.
In the TFI-vehicle group, NeuN+ cells are rarely found, and F-J B+ cells are abundant in the stratum pyramidale (SP). However, in the TFI-20 mg/kg STP group, NeuN+ cells are abundant and F-J B+ cells are very few (arrows) in the SP. Scale bars = 100 μm. (I and i) The mean numbers of NeuN+ cells (I) and F-J B+ cells (i). The bars indicate the means ± SEM (n = 5 or 7, respectively; *p < 0.05 vs. Sham-vehicle or Sham-STP group; #p < 0.05 vs. TFI-vehicle group). NeuN, neuronal nuclei; F-J B, Fluoro-Jade B; CA1, cornu ammonis 1; TFI, transient forebrain ischemia; STP, stiripentol; SO, stratum oriens; SR, stratum radiatum.
© Korean J Physiol Pharmacol