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Fig. 2. Latency time in PAT (A) and mean numbers of errors in 8-ARMT (B) in the Sham-vehicle, Sham-STP (10, 15, and 20 mg/kg), TFI-vehicle and TFI-STP (10, 15, and 20 mg/kg) groups before and after TFI. The substantial trials for PAT are conducted one day before and five days after TFI and gerbils are undergone pre-training trial at 20 min before each substantial trial. In the TFI-20 mg/kg STP group, a significantly delayed latency time in PAT is recorded compared with that in the TFI-vehicle, TFI-10 mg/kg STP and TFI-15 mg/kg STP groups. 8-ARMT is daily performed at three to one day before TFI, and one to five days after TFI. In the TFI-20 mg/kg STP group, the numbers of the errors in 8-ARMT are significantly decreased from two days after TFI. The bars indicate the means ± SEM (n = 7, respectively; *p < 0.05 vs. Sham-vehicle or Sham-STP group; #p < 0.05 vs. TFI-vehicle group). 8-ARMT, 8-arm radial maze test; PAT, passive avoidance test; STP, stiripentol; TFI, transient forebrain ischemia.
Korean J Physiol Pharmacol 2022;26:47-57
© Korean J Physiol Pharmacol