Fig. 3. cGMP and cAMP signaling pathways involved in carbon monoxide (CO)–induced activation of delayed rectifier K⁺ currents (I_K) in human cardiac fibroblasts (HCFs). Summarized current–voltage (I–V) curves from –60 mV to +50 mV show the effects of carbon monoxide-releasing molecule-3 (CORM3, 10 μM) on I_K after pretreatments with (A) KT5823 (a PKG blocker, 1 μM) or (B) ODQ (a soluble guanylate cyclase blocker, 1 μM) (n = 7 each). (C) Bar graphs show summarizing current density changes for the CORM3 effects on I_K after pretreatments with KT5823 or ODQ (at +30 mV). Summarized I–V curves for the effects of CORM3 on I_K after pre-incubation with (D) KT5720 (a PKA blocker, 1 μM) or (E) SQ22536 (an adenylate cyclase blocker, 1 μM). (F) Bar graphs show current density changes at +30 mV for the effects of CORM3 on I_K after pre-incubation with KT5720 or SQ22536 (n = 7 each). Values are mean ± SEM.

Korean J Physiol Pharmacol 2022;26:25-36 https://doi.org/10.4196/kjpp.2022.26.1.25

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