Fig. 5. AKT/PGC1-α/FOXO3a signaling pathways affected muscle atrophy and autophagy regulation.
AKT, protein kinase B; FOXO3a, forkhead box O3; PGC1-α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; MuRF 1, muscle RING finger protein 1; Atrogin-1, muscle-specific F-box protein; LC3, lipidated microtubule-associated protein 1 light chain 3; p62, sequestosome-1; Beclin 1, autophagy-related 6 homolog; BNIP3, BCL2-interacting protein 3.
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