Fig. 4. Expression levels of muscle atrophy-related proteins including 4EBP1, Atrogin-1, and MuRF 1, in the gastrocnemius and soleus muscles.
(A, E) Representative bands. (B) Phospho-4EBP1/total 4EBP1 in gastrocnemius, (C) Atrogin-1/GAPDH in gastrocnemius, (D) MuRF 1/GAPDH in gastrocnemius, (F) phospho-4EBP1/total 4EBP1 in soleus, (G) Atrogin-1/GAPDH in soleus, and (H) MuRF 1/GAPDH in soleus. CON, control (n = 6); CC, cisplatin control (n = 8); CRE, resistance exercise with cisplatin treatment (n = 9); CAE, aerobic exercise with cisplatin treatment (n = 11). MuRF 1, muscle RING finger protein 1; Atrogin-1, muscle-specific F-box protein; GAPDH, glyceraldehyde-3-phosphate dehydrogenase. One-way analysis of variance and Tukey’s post-hoc were used for statistical analysis; units are arbitrary. *p < 0.05, **p < 0.01, ***p < 0.001.
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