Fig. 3. Expression levels of autophagy-related factors in the soleus muscle.
(A, G) Representative bands. (B) Beclin 1/GAPDH, (C) phospho-FOXO3a/total-FOXO3a, (D) p62/GAPDH, (E) BNIP3/GAPDH, (F) LC3-II/I ratio, (H) phospho-mTOR/total-mTOR, (I) phospho-Akt/total-Akt, and (J) PGC1-α/GAPDH. CON, control (n = 6); CC, cisplatin control (n = 8); CRE, resistance exercise with cisplatin treatment (n = 9); CAE, aerobic exercise with cisplatin treatment (n = 11). AKT, protein kinase B; FOXO3a, forkhead box O3; PGC1-α, peroxisome proliferator-activated receptor gamma coactivator 1-alpha; LC3, lipidated microtubule-associated protein 1 light chain 3; p62, sequestosome-1; Beclin 1, autophagy-related 6 homolog; BNIP3, BCL2-interacting protein 3; GAPDH, glyceraldehyde-3-phosphate dehydrogenase. One-way analysis of variance and Tukey’s post-hoc were used for statistical analysis; units are arbitrary. *p < 0.05, **p < 0.01, ***p < 0.001.
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