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Fig. 4. Effects of vehicle and antagonists on isometric contractions of mouse vas deferens produced by 40 pulses at 10 Hz, expressed as % of control. The effects of (A) vehicle (veh) (4 additions), (B) BMY7378 (BMY) (10 nM–1 µM), (C) RS100329 (0.1 nM–100 nM), (D) prazosin (praz) (1 nM–1 µM) and (E) RS17053 (100 nM–10 µM) on isometric contractions to field stimulation with 40 pulses at 10 Hz in mouse vas deferens, expressed as a percentage of the respective control response (see for responses expressed as absolute tension). Values are presented as mean ± SEM from 6 experiments, except for (E), where n = 4. Responses in the presence of antagonist were compared with the effects of respective vehicle by 2 way analysis of variance and Bonferroni post-hoc test. Asterisks denote effects of antagonist significantly different from the effects of vehicle at a given time point, and are colour coded to match the antagonist concentration symbol colour: *p < 0.05; **p < 0.01; ***p < 0.001.
Korean J Physiol Pharmacol 2021;25:525-532
© Korean J Physiol Pharmacol