Table. 1.

Antagonist potency at producing 50% inhibition (pIC50, –log M) of contractions of mouse vas deferens produced by a single stimulus, and by 10 Hz stimulation, both peak response (0.8 sec) and plateau response (3 sec)

Antagonist Single pulse 1 Hz (3rd pulse) 10 Hz peak (0.8 sec) 10 Hz plateau (3 sec)
BMY7378 6.58 ± 0.14 ND ND ND
RS100329 8.46 ± 0.28 ND 8.19 ± 0.10 ND
Prazosin 8.05 ± 0.28 ND 7.94 ± 0.22 7.71 ± 0.27
RS17053 - - 5.24 ± 0.14 5.74 ± 0.49

Values are presented as mean ± SEM from 6 experiments, except for RS17053, where n = 4. ND, not determined, 50% inhibition not reached.

Korean J Physiol Pharmacol 2021;25:525-532 https://doi.org/10.4196/kjpp.2021.25.6.525
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