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Fig. 4. Effects of 5-HT receptor antagonism on the suppressive properties of rosavin against oxaliplatin-induced cold allodynia in mice. Mice with allodynia were randomly administered with WAY-100635 (n = 6), MDL-72222 (n = 6), or an equivalent volume of the vehicles (saline, the vehicle of WAY-100635, n = 5 or 20% DMSO, the vehicle of MDL-72222, n = 5) 15 min prior to rosavin treatment at days 3 to 5. Cold sensitivity was assessed before antagonist administration (Before) and 30 min after rosavin application (After). Data are expressed as mean ± SEM; **p < 0.01, ***p < 0.001, vs. Before; by Bonferroni post-hoc test after two-way analysis of variance (ANOVA).
Korean J Physiol Pharmacol 2021;25:489-494 https://doi.org/10.4196/kjpp.2021.25.5.489
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