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Fig. 3. Roles of the serotonergic system in mediating ameliorative effects of rosavin against oxaliplatin-induced cold allodynia in mice. Pretreatment with para-chlorophenylalanine (PCPA) (n = 8) was performed prior to oxaliplatin injection for three consecutive days, and naloxone (n = 6) was administered 15 min before rosavin administration. An equivalent volume of saline was pre-administered to controls (n = 12). Mice presenting neuropathic pain-like behavior were subjected to the acetone drop assay before rosavin treatment (10 mg/kg, Before) and 30 min after administration (After). Data are expressed as mean ± SEM; ***p < 0.001, vs. Before; by Bonferroni post-hoc test after two-way analysis of variance (ANOVA).
Korean J Physiol Pharmacol 2021;25:489-494
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