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Fig. 9. Apoptosis induced the PAMAMG3 derivative/pJDK-apoptin. (A, B) Annexin V staining of PAMAMG3 derivative/pJDK-apoptin using flow cytometry. GBL-14 cells and human dermal fibroblasts (HDFs) were incubated with PAMAMG3, PAMAMG3-KRRR, and PAMAMG3-HKRRR with pJDK and pJDK-apoptin. After 24 h post-exposure, apoptosis levels for each polyplex were assessed by flow cytometry. Representative histograms showing four quadrants (Q1: percentage of necrosis, Q2: percentage of late apoptosis, Q3: percentage of live cells, and Q4: percentage of early apoptosis).
Korean J Physiol Pharmacol 2021;25:467-478
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