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Fig. 8. Cytotoxicity of the PAMAMG3 derivative/apoptin complexes. (A, B) GBL-14 cells and (C, D) human dermal fibroblasts (HDFs) were incubated with PAMAMG3, PAMAMG3-KRRR, and PAMAMG3-HKRRR with pJDK or pJDK-apoptin for 24 h. After 24 h post-exposure, cytotoxicity of each polymer and polyplex was determined using the WST-1 assay. Values are expressed as mean ± SD of three independent experiments (n = 3). Statistical analyses were conducted using the unpaired two-tailed Students t-test. Asterisks indicate statistically significant values (**p < 0.01, *p < 0.1, and not significant [n.s.] [p > 0.05]).
Korean J Physiol Pharmacol 2021;25:467-478
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