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Fig. 1. Synthesis of nonviral gene delivery systems. (A) 1H NMR spectra of PAMAMG3, PAMAMG3-KRRR, and PAMAMG3-HKRRR. (B) The synthesis scheme of PAMAM derivates conjugated with nuclear localization signal (NLS) peptides. (C) Scheme 1. Diagram of the endocytic pathway and the formation of PAMAMG3-HKRRR/pJDK-apoptin complex and apoptin gene delivery into the nucleus. Apoptin promotes apoptotic cell death of GBL-14 cells.
Korean J Physiol Pharmacol 2021;25:467-478
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