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Fig. 5. Effect of melatonin on the expression of sodium-potassium-chloride co-transporter 1 (NKCC1) and potassium-chloride co-transporter 2 (KCC2) in dorsal raphe nucleus (DRN) neurons. (A) Western blots showing NKCC1 and KCC2 expression in DRN slices with melatonin treatment (0.1, 1, and 10 μM) for 4 h. Averaged optical density of NKCC1 (B) and KCC2 (C) expression after 4 h melatonin incubation, expressed relative to each control level. Each column represents the mean and SEM of data from 10–12 experiments. ***p < 0.001, *p < 0.05 compared with control.
Korean J Physiol Pharmacol 2021;25:449-457
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