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Fig. 2. Sitagliptin inhibited autophagy in aortas in diabetic rats. (A) Representative pictures of immunohistochemistry of LC3 (×200). (B, C) Representative Western blot bands for the protein expression of LC3. (D, E) Representative Western blot bands for the protein expression of beclin-1. (F, G) Representative Western blot bands for the protein expression of LAMP1/2 of aortas in Sitagliptin-treated diabetic rats. (H) The Cathepsin B/D activity results of aortas in Sitagliptin-treated diabetic rats were presented. n = 4–5. LC3, microtubule-associated protein 1 light chain 3; LAMP1/2, lysosomal-associated membrane protein 1/2; DM, diabetes mellitus. *p < 0.05 vs. control group, **p < 0.01 vs. control group, #p < 0.05 vs. DM group, ##p < 0.01 vs. DM group, ###p < 0.001 vs. DM group.
Korean J Physiol Pharmacol 2021;25:425-437 https://doi.org/10.4196/kjpp.2021.25.5.425
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