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Fig. 1. Sitagliptin improved blood glucose and damage of aortas in diabetic rats. (A) Variation of FBG in the duration of treatments. (B) Variation of random blood glucose in the period of treatments. (C) The arrows point to endothelial cells. H&E staining of aortas (×200). (D) The thickness of artery wall of rats in each group. (E) Serum VCAM-1 level of rats in each group. (F–J) Representative Western blot bands for the protein levels of E-selection, ICAM-1, VWF, and TM in sitagliptin-treated rats. Data are expressed as means ± SD, n = 5–8. FBG, fasting blood glucose; H&E, hematoxylin and eosin; VCAM-1, vascular adhesion molecule-1; DM, diabetes mellitus; ICAM-1, intercellular adhesion molecule 1; VWF, Von Willebrand factor; TM, thrombomodulin. *p < 0.05 vs. control group, ***p < 0.001 vs. control group, #p < 0.05 vs. DM group, ###p < 0.001 vs. DM group.
Korean J Physiol Pharmacol 2021;25:425-437
© Korean J Physiol Pharmacol