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Fig. 7. c-Jun N-terminal kinase (JNK) and curcumin show similar effects on H3K9 acetylation near the promoter region of caspase-3/-9. The enrichment of acH3K9 in the promoter regions of (A) caspase-3 and (B) caspase-9 in SHAM group, IRI group, IRI/SP group and IRI/Cur group. The binding level of CREB-binding protein (CBP)/p300 to the promoter region of (C) caspase-3 and (D) caspase-9 in above groups. (E) histone acetyltransferase (HAT) activity in above groups. Results are expressed as mean ± SD. Statistical significance was determined by One-way ANOVA followed by Fisher’s Least Significant Difference test. n = 8 per group. IRI, ischemia/reperfusion injury; SP, SP600125; Cur, curcumin. *p < 0.05 vs. SHAM group; #p < 0.05 vs. IRI group.
Korean J Physiol Pharmacol 2021;25:413-423
© Korean J Physiol Pharmacol