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Fig. 6. c-Jun N-terminal kinase (JNK) and curcumin show similar effects on p300/CREB-binding protein (CBP) and caspase3/9 expression. (A) The protein levels of caspase-3/-9 and cleaved caspase-3/-9 in SHAM group, IRI group, IRI/SP group and IRI/Cur group. (B) The level of histone acetylation related proteins including p300/CBP and acetyl-histone H3 in above groups. (C) The protein level of phosphorylated JNK in above groups. Results are expressed as mean ± SD. Statistical significance was determined by One-way ANOVA followed by Fisher’s Least Significant Difference test. n = 8 per group. IRI, ischemia/reperfusion injury; SP, SP600125; Cur, curcumin. *p < 0.05 vs. SHAM group; #p < 0.05 vs. IRI group.
Korean J Physiol Pharmacol 2021;25:413-423
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