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Fig. 5. Histone acetylation near the promoter region of caspae-3 and caspase-9. ChiP assay was used to detect acH3K9 level in the upstream region of (A) caspase-3 (1,000 bp) and (B) caspase-9 (1,000 bp). The enrichment of CREB-binding protein (CBP)/p300 in the promoter region of (C) caspase-3 and (D) caspase-9 in SHAM group, IRI group and IRI/Cur group. (E) The protein levels of p300 and CBP in above groups. (F) Quantification results of western blotting. Results are expressed as mean ± SD. Statistical significance was determined by One-way ANOVA followed by Fisher’s Least Significant Difference test. n = 8 per group. IRI, ischemia/reperfusion injury; Cur, curcumin. *p < 0.05 vs. SHAM group; #p < 0.05 vs. IRI group.
Korean J Physiol Pharmacol 2021;25:413-423
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