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Fig. 5. Histological analysis of hepatic tissue sections from vehicle and N-acetyl-p-aminophenol (APAP)-treated mice in the presence or absence of tissue factor (TF) deoxyoligonucleotides (ODNs). Normal histologic features are seen in vehicle treated animals. However, APAP-injected and APAP + TF-SC mice sections displayed alteration in the general architectures in the form of ischemia, necrosis (black arrowheads), hemorrhage (long arrows), loss of sinusoidal architecture and fatty degeneration (yellow arrowheads). Whereas APAP + TF-AS treated mice showed normal tissue architectures (H&E, magnification 200×, scale bar 100 µm).
Korean J Physiol Pharmacol 2021;25:385-393
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