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Fig. 2. Effect of N-acetyl-p-aminophenol (APAP) treatment with or without tissue factor (TF) deoxyoligonucleotides (ODNs) on liver tissue expression of fibrin protein. (A) Microscopic appearance of fibrin protein expression in APAP treated mice in the presence or absence of TF ODNs using immunofluorescence technique. Fibrin protein is increased in the liver of mice treated with APAP and APAP + TF-SC. However, APAP + TF-AS treated mice section showed lower fibrin protein expression compared to APAP treatment alone (arrows). CV, central vein (magnification 200×). (B) Histogram of green fluorescence intensity. (C) Figure of TF representing the quantitative fluorescence intensity of six fields per section for at least six mice per group. Data are represented as means ± SD. aSignificantly different from vehicle treated mice. bSignificantly different from APAP-treated mice using one-way ANOVA followed by Tukey-Kramer test as multiple comparison at p < 0.05 (magnification 200×, scale bar 100 µm).
Korean J Physiol Pharmacol 2021;25:385-393
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