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Fig. 3. Effect of lutein on (A) peroxisome proliferator-activated receptor gamma (PPARγ), (B) peroxisome proliferator-activated receptor gamma (PPARγ) mRNA and (C), nuclear factor erythroid 2-related factor 2 (Nrf2) expressions respectively, in low (250 mg/kg) and high (500 mg/kg) dose vancomycin-induced renal injury in mice. Results are represented as mean ± SD. L, lutein; VL, 250 mg/kg vancomycin; VH, 500 mg/kg vancomycin; VL + L, 250 mg/kg + lutein; VH + L, 500 mg/kg + lutein. *Represent significant difference (p < 0.05) between control and vancomycin treated groups, while represents significant difference (p < 0.05) between vancomycin treated and lutein plus vancomycin treatment groups. #Represents significant difference (p < 0.05) between control and lutein.
Korean J Physiol Pharmacol 2021;25:321-331
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