Fig. 5. Luteolin prevents DNA from hydrogen peroxide (H2O2)-induced damage.
(A, B) House Ear Institute-Organ of Corti 1 (HEI-OC1) cells were transfected with 80 nM siRNAs of sirtuin 1 (SIRT1) or p53, then incubated in 2 μM luteolin for 12 h, followed by 30 μM H2O2 treatment for additional 3 days. Comet assay was performed as described in Methods. Data show the results of one of three independent experiments. *p < 0.05 vs. H2O2, #p < 0.05 vs. luteolin/H2O2/control siRNA.
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