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Fig. 1. Inhibitory effects of five major constituent chemical compounds in 30% Flos magnoliae ethanolic extract (FMEtOH) on the ORAI1 current (IORAI1) in HEK293T cells co-expressing ORAI1 and stromal interaction molecule 1 (STIM1). (A) Representative current (I)–voltage (V) relationship curve showing IORAI1 by various constituents (100 µM) and BTP2. (B) Normalized IORAI1 inhibition histograms indicating treatment with various constituents (100 µM) at −120 mV. Values are presented as mean ± SEM. *p < 0.05 and ****p < 0.0001 compared to control (IORAI1).
Korean J Physiol Pharmacol 2021;25:251-258
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