Fig. 5. Influence of remote ischemic preconditioning (RIPC), hydrogen sulfide (H₂S) donor, H₂S precursor and HIF-1α inhibitor on ischemia-reperfusion-induced changes in the nuclear: cytosolic ratio (in percentage) of Nrf2 (A) and HIF-1α levels (B) in young and old rat hearts, after 120 min of reperfusion. The values of normal groups were assigned 100% and values of all other groups were represented in the form of percentage of normal group. HIF, hypoxia-inducible factor; Nrf2, nuclear factor erythroid 2-related factor 2; NaHS, sodium hydrosulfide; LC, l-cysteine. (A) ^ap < 0.05 vs. control; ^bp < 0.05 vs. RIPC in young; ^cp < 0.05 vs. RIPC in old; ^dp < 0.05 vs. NaHS (20 µM/kg) and RIPC in old; ^ep < 0.05 vs. LC (20 mg/kg) and RIPC in old. (B) ^ap < 0.05 vs. normal; ^bp < 0.05 vs. control; ^cp < 0.05 vs. RIPC in young; ^dp < 0.05 vs. RIPC in old; ^ep < 0.05 vs. NaHS (20 µM/kg) and RIPC in old; ^fp < 0.05 vs. LC (20 mg/kg) and RIPC in old.

Korean J Physiol Pharmacol 2021;25:239-249 https://doi.org/10.4196/kjpp.2021.25.3.239

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