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Fig. 1. Influence of remote ischemic preconditioning (RIPC), hydrogen sulfide (H2S) donor, H2S precursor and HIF-1α inhibitor on ischemia-reperfusion-induced LDH-1 (A), CK-MB (B) and cTnT (C) release in young and old rats. The levels were measured in the coronary effluent immediately before subjecting to ischemia and immediately after initiating reperfusion. HIF, hypoxia-inducible factor; LDH, lactate dehydrogenase; CK, creatine kinase; cTnT, cardiac troponin T; NaHS, sodium hydrosulfide; LC, l-cysteine. ap < 0.05 vs. control before ischemia; bp < 0.05 vs. control during reperfusion; cp < 0.05 vs. RIPC in young; dp < 0.05 vs. RIPC in old; ep < 0.05 vs. NaHS (20 µM/kg) and RIPC in old; fp < 0.05 vs. LC (20 mg/kg) and RIPC in old.
Korean J Physiol Pharmacol 2021;25:239-249
© Korean J Physiol Pharmacol