Fig. 4. Effect of the cAMP signaling pathway on the carbon monoxide (CO)-induced IBK activation of human cardiac fibroblasts (HCFs).
(A) Representative currents and current–voltage (I–V) curves showing the summary of the current density changes regarding the effect of 8-Br-cAMP (300 μM) on IBK (n = 8, *p < 0.05, **p < 0.01 vs. the control). (B) Bar graphs at +50 mV show the summarized current density changes by 8-Br-cAMP (300 μM, n = 8) on the IBK. (C) I–V curves and (D) bar graphs show the summarized current density changes for the effect of 10 μM CO-releasing molecule (CORM)-2 (n = 8) or 10 μM CORM-3 (n = 8) on IBK after pre-treatment with KT5720 (1 μM) for 20 min. (E) I–V curves and (F) bar graphs show the summarized current density changes for the effect of 10 μM CORM-2 (n = 8) or 10 μM CORM-3 (n = 8) on IBK after pre-treatment with SQ22536 (1 μM) for 20 min.
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