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Fig. 4. PF improves the inflammatory infiltration of hippocampal pyramidal cells and reduces the expression of pro-inflammatory cytokines. Representative photomicrographs of H&E staining in the CA3 (Bar = 100 μm) region of hippocampus in different groups (A). ELISA showed that PF treatment decreased the expression of TNF-α (B), IL-6 (C), and IL-8 (D) caused by Cuff. The data represent the mean ± standard deviation. n = 4. PF, paeoniflorin. ***p < 0.001 vs. Sham group; #p < 0.05, ##p < 0.01, ###p < 0.001 vs. Cuff group.
Korean J Physiol Pharmacol 2021;25:217-225
© Korean J Physiol Pharmacol