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Fig. 2. Effect of mangiferin on cardiac collagen deposition. (A) Histological analysis for the effects of mangiferin on D-gal-induced collagen deposition in rat heart sections stained by masson and sirius red. The proportion of masson- and sirius red-positive area in sections were measured using Image-Pro Plus 6.0. Images were captured at 200× magnification. Scale bar of 100 μm was marked. (B) The proportion of masson-positive area and sirius red in heart sections. Values (n = 8) were presented as mean ± standard deviation. D-gal, D-galactose; Veh group, vehicle control group; Aging group, D-gal-induced aging group. **p < 0.01 compared to the Aging group. ##p < 0.01 compared to the Veh group.
Korean J Physiol Pharmacol 2021;25:131-137
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