Fig. 6. Effects of gamma-aminobutyric acid (GABA)-salt on the expression of GABA_B receptor and its function in vascular smooth muscle cells (VSMCs). (A) The qRT-PCR graph showing the mRNA expressions of GABA_B receptor in media, salt or GABA-salt treated mouse vascular smooth muscle cell (MOVAS). (B) Immunofluorescent images showing Endothelin-1 (ET-1) (green, nuclei; blue) expressions in media, salt or GABA-salt treated MOVAS. Scale bar = 50 µm. (C, D) Immunohistochemistry staining image and graph showing proliferating cell nuclear antigen (PCNA), as proliferating cell marker, positive cell (brown, arrows) in hypertensive mice. Scale bar = 50 µm. H&E staining image and graph showing changes of vessel thicknesses in hypertensive mice. Scale bar = 500 µm. *p < 0.05, and **p < 0.01 vs. culture media or normal diet (ND); ^$p < 0.05 vs. salt or high cholesterol diet (HCD)/salt.

Korean J Physiol Pharmacol 2021;25:27-38 https://doi.org/10.4196/kjpp.2021.25.1.27

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