Fig. 3. Inhibitory effects of gamma-aminobutyric acid (GABA)-salt on expressions of type 1/type 2 macrophage (M1/M2) and associated cytokines in high cholesterol diet (HCD)-induced mouse model.
(A) Immunohistochemistry images showing M1 macrophages (CD86; brown, arrows). Scale bar = 40 µm. (B) The qRT-PCR graph showing mRNA expressions of M1 (CD86) macrophage marker. (C) The qRT-PCR graph showing the mRNA expressions of M1 related cytokines including TNF-α and iNOS. (D) Immunohistochemistry images showing M2 macrophages (CD206; brown, arrow). Scale bar = 40 µm. (E) The qRT-PCR graph showing mRNA expressions of M2 (CD206) macrophage marker. (F) The qRT-PCR graph showing the mRNA expressions of M2 related cytokines including TGF-β and Arg-1. NS, not significant compared to HCD/salt. *p < 0.05, and **p < 0.01 vs. normal diet (ND) and $p < 0.05, and $$p < 0.01 vs. HCD/salt.
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