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Fig. 2. Regulation of blood pressure, water intake, urine volume and renal function of gamma-aminobutyric acid (GABA)-salt in high cholesterol (HCD) diet-induced mouse model. Blood pressures were measured at 3, 4 and 5 weeks. (A–C) Graphs of the blood pressures of mice fed a normal diet (ND, circle), a high cholesterol diet and normal saline (HCD/salt, square) diet, or a high cholesterol and GABA-salt (HCD/GABA-salt, triangle) diet showing; (A) systolic blood pressures, (B) diastolic blood pressures, and (C) mean arterial blood pressures. (D) Water intake and (E) urine volume were measured at 5 weeks and blood chemistry tests including (F) serum creatinine and (G) BUN show kidney function in ND group, HCD/salt group and HCD/GABA-salt group. BUN, blood urea nitrogen. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. ND; and $p < 0.05, $$p < 0.01, and $$$p < 0.001 vs. HCD/Salt.
Korean J Physiol Pharmacol 2021;25:27-38
© Korean J Physiol Pharmacol