Fig. 6. Eupatilin reduced oxidative stress and inflammation in the liver tissue. H&E-stained liver samples in the control, vehicle, silymarin (positive control), eupatilin 10 mg/kg, eupatilin 30 mg/kg, and eupatilin 100 mg/kg groups. Representative photomicrographs of each sample were captured at (A) 20× (scale bar, 50 μm) and (B) 40× (scale bar, 20 μm) magnifications. The red arrow indicated the fat accumulation in liver tissue. The black arrow indicated sinusoidal dilation in liver tissue. Scale bar Control group: saline + 0.1% CMC-Na, vehicle group: 7 g/kg ethanol + 0.1% CMC-Na, silymarin (positive control) group: 7 g/kg ethanol + silymarin 10 mg/kg, eupatilin 10 mg/kg: 7 g/kg ethanol + eupatilin 10 mg/kg, eupatilin 30 mg/kg: 7 g/kg ethanol + eupatilin 30 mg/kg, and eupatilin 100 mg/kg: 7 g/kg ethanol + eupatilin 100 mg/kg. CMC-Na, sodium carboxymethyl cellulose.
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