Fig. 4. Eupatilin reduced plasma MDA and improved antioxidant status in the ALD model. The activities of (A) MDA and (B) SOD and the level of (C) GSH were measured in rat plasma (n = 7). Control group: saline + 0.1% CMC-Na, vehicle group: 7 g/kg ethanol + 0.1% CMC-Na, silymarin (positive control) group: 7 g/kg ethanol + silymarin 10 mg/kg, eupatilin 10 mg/kg: 7 g/kg ethanol + eupatilin 10 mg/kg, eupatilin 30 mg/kg: 7 g/kg ethanol + eupatilin 30 mg/kg, and eupatilin 100 mg/kg: 7 g/kg ethanol + eupatilin 100 mg/kg. Data are expressed as mean ± standard error of the mean. CMC-Na, sodium carboxymethyl cellulose; ALD, alcoholic liver disease; MDA, malondialdehyde; SOD, superoxide dismutase; GSH, glutathione. #p < 0.05, ##p < 0.01 vs. the control group, *p < 0.05, **p < 0.01 vs. the vehicle group.
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