Fig. 2. Eupatilin reduced plasma AST and ALT in the alcoholic liver disease model. (A) AST and (B) ALT levels were measured in the rat plasma (n = 7). Control group: saline + 0.1% CMC-Na, vehicle group: 7 g/kg ethanol + 0.1% CMC-Na, silymarin (positive control) group: 7 g/kg ethanol + silymarin 10 mg/kg, eupatilin 10 mg/kg: 7 g/kg ethanol + eupatilin 10 mg/kg, eupatilin 30 mg/kg: 7 g/kg ethanol + eupatilin 30 mg/kg, and eupatilin 100 mg/kg: 7 g/kg ethanol + eupatilin 100 mg/kg. Data are expressed as mean ± standard error of the mean. CMC-Na, sodium carboxymethyl cellulose; ALD, alcoholic liver disease; AST, aspartate aminotransferase; ALT, alanine aminotransferase. ^##p < 0.01 vs. control group, *p < 0.05, **p < 0.01 vs. vehicle group.

Korean J Physiol Pharmacol 2020;24:385-394 https://doi.org/10.4196/kjpp.2020.24.5.385

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