Fig. 3. S109 inhibited the activity and expression of MMP2 via inactivation of STAT3 signaling. (A, B) Representative picture and quantitative MMP2 activity of gelatin zymography assay. Cells were treated with S109 at the indicated concentrations, and then the gelatin zymography assay was performed. (C–F) The effects of S109 on MMP2 expression by Western blot analysis. (G–J) Phosphorylated STAT3 and total STAT3 expression were examined in U87 and U251 cells treated with S109. All data presented here are the means ± standard error of the mean from three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001.
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