Effects of α-isocubebene (ICB) on phenylephrine (PE)- and norepinephrine (NE)-induced contractions in mouse thoracic aorta.
Under pretreatment with vehicle or ICB (1–10 µg/ml), PE (10−7−3×10−6 M) (A) or NE (10−8−3×10−7 M) (B) was added in a step-wise manner to elicit vasocontraction. Tracings are representative of 4–5 independent experiments. Bottom: percentage vasocontraction represents contraction relative to that elicited by 60 mM KCl. Results were presented as the means±SEM of 4–5 independent experiments. *p<0.05; **p<0.01 vs. corresponding value in Vehicle.
