Fig. 4.

PM10-induced [Ca²⁺]_i signal is required for the involvement of TRPM2 activation.

(A) Changes in [Ca²⁺]_i induced by 50 µg/mL PM10. 50 µg/mL PM10 induced [Ca²⁺]_i signaling in the presence of TRPM2 inhibitors: (B) 75 µM 2-APB, (C) 10 µM CLZ, or (D) 10 µM ACA. Top bars indicate the extracellular solution type applied to cells. Traces shown were obtained from average signal. (E) ΔCa²⁺ was calculated at the indicated dotted line. Results are presented as mean±SEM, and ^*p values of <0.01 were considered significant.

Korean J Physiol Pharmacol 2017;21:327-334 https://doi.org/10.4196/kjpp.2017.21.3.327

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