HFD increased Ang II-induced vascular smooth muscle contraction.
The graph summarized KCl-induced contraction (a), Ang II-induced contraction (b), and Ang II-induced contraction normalized by KCl-induced contraction (c) of ND or HFD-fed rat aorta. Endothelium denuded aortic ring was treated with 50 mM KCl or 10 nM of Ang II. Ang II-induced aortic contraction was higher in HFD group than ND group. Data are presented as means±SE (n=4). *p<0.05 vs. Ang II-induced contraction of ND-fed rat aorta. N, normal; HF, high fat. (d, e) Representative tracings of contractile responses in normal diet group (d) or high fat diet group (e). Traces show KCl-induced contraction followed by Ang II-induced contraction.
