Korean J Physiol Pharmacol 2013 Apr; 17(2): 169-173
Ask캇n Tas Hekimoglu1, Gulten Toprak2, Hasan Akkoc1, Osman Evliyaoglu2, Selver Ozekinci3, and Ilker Kelle1
Oxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia-Reperfusion in Rats
Departments of 1Pharmacology, 2Clinical Biochemistry and 3Pathology, Faculty of Medicine, Dicle University, 21280 Diyarbak캇r, Turkey
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Renal ischemia-reperfusion (IR) causes remote liver damage. Oxytocin has anti-inflammatory and antioxidant effects. The main purpose of this study was to evaluate the protective function of oxytocin (OT) in remote liver damage triggered by renal IR in rats. Twenty four rats were randomly divided into four different groups, each containing 8 rats. The groups were as follows: (1) Sham operated group; (2) Sham operated+OT group (3) Renal IR group; (4) Renal IR+OT group. OT (500Ռg/kg) was administered subcutaneously 12 and 24 hours before and immediately after ischemia. At the end of experimental procedure, the rats were sacrificed, and liver specimens were taken for histological assessment or determination of malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), paraoxonase (PON-1) activity and nitric oxide (NO). The results showed that renal IR injury constituted a notable elevation in MDA, TOS, Oxidative stress index (OSI) and significantly decreased TAS, PON-1 actvity and NO in liver tissue (p竊0.05). Additionally renal IR provoked significant augmentation in hepatic microscopic damage scores. However, alterations in these biochemical and histopathological indices due to IR injury were attenuated by OT treatment (p竊0.05). These findings show that OT ameliorates remote liver damage triggered by renal ischemia-reperfusion and this preservation involves suppression of inflammation and regulation of oxidant-antioxidant status.
Keyword : Inflammation, Ischemia-reperfusion, Oxidative stress, Oxytocin, Remote liver injury

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